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KMID : 1094720220270060900
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Biotechnology and Bioprocess Engineering
2022 Volume.27 No. 6 p.900 ~ p.908
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Identification Process and Physiological Properties of Transporters of Carboxylic Acids in Escherichia coli
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Kim Seung-Jin
Lee Hye-Kyung
Jung Gyoo-Yeol
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Abstract
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Carboxylic acids (CAs) are important organic compounds that participate in various cellular metabolic pathways. Since maintenance of intracellular CA concentration is vital for cell growth, cells utilize transporter systems to regulate CA concentration based on the cell growth phase and extracellular environmental conditions. Metabolic engineering has received a considerable amount of attention in recent years, and although the importance of membrane transporters has been overlooked for decades, the scientific community and biotechnology companies have finally turned their attention to transporter engineering as a method to improve production efficiency in microbial cell factories. Several physiological and genetic studies conducted to date have deepened our understanding of CA transporters. In this review, we summarized the current knowledge about CA transporters in Escherichia coli, including the identification process and physiological properties of transporters, and regulation of transporter expression and activity.
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KEYWORD
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carboxylic acids, carboxylic acid transporter, transporter engineering, microbial cell factories, transport identification methods, transport assays
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